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首页-小分子抑制剂&激动剂-Epigenetics-Sirtuin -SirReal2
SirReal2

Chemical Structure : SirReal2

CAS No.: 709002-46-0

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SirReal2 (MZ25;MZ-25;SirReal 2)

货号: PC-60123Not For Human Use, Lab Use Only.

SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM.

规格 价格 库存 数量
25 mg ￥1980 In stock
100 mg ￥4980 In stock
200 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SirReal2 (MZ25) is a novel potent, selective Sirtuin 2 (Sirt2) inhibitor with IC50 of 0.435 uM.
SirReal2 displays >1,000-fold more potently than Sirt1, Sirt3, Sirt4, Sirt5 and Sirt6.
SirReal2 increases α-tubulin acetylation in HeLa cells, significantly results in a dose-dependent depletion of BubR1.

物理化学性质&存储条件

分子量 420.549
分子式 C22H20N4OS2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-((4,6-dimethylpyrimidin-2-yl)thio)-N-(5-(naphthalen-1-ylmethyl)thiazol-2-yl)acetamide

参考文献

1. Rumpf T, et al. Nat Commun. 2015 Feb 12;6:6263.

2. Schiedel M, et al. Angew Chem Int Ed Engl. 2016 Feb 5;55(6):2252-6.

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