Siomycin A |CAS:12656-09-6 Probechem Biochemicals

Chemical Structure : Siomycin A

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Siomycin A (NSC285116;NSC 285116)

货号: PC-63570Not For Human Use, Lab Use Only.

Siomycin A (NSC 285116) is an antibiotic thiazole inhibitor of the oncogenic transcription factor FOXM1, down-regulates the transcriptional activity as well as the protein and mRNA abundance of FoxM1.

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生物&药学活性

Siomycin A (NSC 285116) is an antibiotic thiazole inhibitor of the oncogenic transcription factor FOXM1, down-regulates the transcriptional activity as well as the protein and mRNA abundance of FoxM1.
Siomycin A (NSC 285116) represses the downstream target genes of FoxM1, such as Cdc25B, Survivin, and CENPB.
Siomycin A (NSC 285116) reduces anchorage-independent growth of cells in soft agar, selectively induces apoptosis in transformed but not normal cells.

物理化学性质&存储条件

分子量	1648.84
分子式	C71H81N19O18S5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Radhakrishnan SK, et al. Cancer Res. 2006 Oct 1;66(19):9731-5.

2. Joshi K, et al. Stem Cells. 2013 Jun;31(6):1051-63.

3. Briest F, et al. Oncotarget. 2015 Apr 10;6(10):8185-99.

4. Penke LR, et al. J Clin Invest. 2018 May 7. pii: 87631. doi: 10.1172/JCI87631.

Siomycin A (NSC285116;NSC 285116)

生物&药学活性

物理化学性质&存储条件

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Siomycin A (NSC285116;NSC 285116)

生物&药学活性

物理化学性质&存储条件

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