Sinefungin | Methyltransferase inhibitor | Probechem Biochemicals

Chemical Structure : Sinefungin

CAS No.: 58944-73-3

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Sinefungin (A 9145, RP32232)

货号: PC-62408Not For Human Use, Lab Use Only.

Sinefungin (A 9145, RP 32232) is a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 uM).

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2 mg	￥2480	In stock
5 mg	￥3480	In stock
10 mg	￥5580	In stock
25 mg		Get quote

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生物&药学活性

Sinefungin (A 9145, RP 32232) is a non-selective inhibitor of SET domain-containing methyltransferases in the study of epigenetic regulation (IC50 values range from 0.1-20 uM).
Sinefungin is a nucleoside structurally related to S-adenosylhomocysteine and S-adenosylmethionine that isolated from Streptomyces.
Sinefungin demonstrates high in vivo toxicity.
Sinefungin inhibits SET7/9 and ameliorates renal fibrosis by inhibiting H3K4 methylation

物理化学性质&存储条件

分子量	381.4
分子式	C15H23N7O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S,5S)-2,5-Diamino-6-((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)hexanoic acid

参考文献

1. Tisi D, et al. ACS Chem Biol. 2016 Nov 18;11(11):3093-3105.

2. van Haren MJ, et al. Biochemistry. 2016 Sep 20;55(37):5307-15.

Sinefungin (A 9145, RP32232)

生物&药学活性

物理化学性质&存储条件

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Sinefungin (A 9145, RP32232)

生物&药学活性

物理化学性质&存储条件

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