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Sinbaglustat

Chemical Structure : Sinbaglustat

CAS No.: 441061-33-2

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Sinbaglustat (ACT-519276, OGT2378)

货号: PC-26890Not For Human Use, Lab Use Only.

Sinbaglustat (OGT2378) is an orally available, blood-brain barrier permeable dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2), Sinbaglustat is 50‐fold more potent in inhibiting GBA2 than GCS.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Sinbaglustat (OGT2378) is an orally available, blood-brain barrier permeable dual inhibitor of glucosylceramide synthase (GCS) and non-lysosomal glucosyl ceramidase (GBA2), Sinbaglustat is 50‐fold more potent in inhibiting GBA2 than GCS.

物理化学性质&存储条件

分子量 233.31
分子式 C11H23NO4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,3R,4R,5S)-2-(Hydroxymethyl)-1-pentylpiperidine-3,4,5-triol

参考文献

1. Melchior M, et al. J Clin Pharmacol. 2021 Jul;61(7):932-938.

2. Aravind A, et al. J Org Chem. 2009 Apr 3;74(7):2858-61.

3. Weiss M, et al. Cancer Res. 2003 Jul 1;63(13):3654-8.

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