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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-HCV-Simeprevir
Simeprevir

Chemical Structure : Simeprevir

CAS No.: 923604-59-5

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Simeprevir (TMC-435, TMC435, TMC435350, TMC-435350)

货号: PC-42480Not For Human Use, Lab Use Only.

Simeprevir (TMC435, TMC435350) is a potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.

规格 价格 库存 数量
5 mg ￥880 In stock
10 mg ￥1280 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Simeprevir (TMC435, TMC435350) is a potent, orally available inhibitor of HCV NS3/4A protease with Ki of 0.36 nM, replicon EC50 of 7.8 nM.
Simeprevir inhibits NS3/4A proteases of genotypes 1a and 1b with Ki of 0.5 and 0.4 nM, shows synergistic effect with α-Interferon and an NS5B inhibitor in the replicon model and additive with ribavirin.
Simeprevir exerts favorable pharmacokinetic profile and antiviral activity in vivo.

物理化学性质&存储条件

分子量 749.9391
分子式 C38H47N5O7S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Cyclopenta[c]cyclopropa[g][1,6]diazacyclotetradecine-12a(1H)-carboxamide, N-(cyclopropylsulfonyl)-2,3,3a,4,5,6,7,8,9,11a,12,13,14,14a-tetradecahydro-2-[[7-methoxy-8-methyl-2-[4-(1-methylethyl)-2-thiazolyl]-4-quinolinyl]oxy]-5-methyl-4,14-dioxo-, (2R,3aR,1

参考文献

1. Raboisson P, et al. Bioorg Med Chem Lett. 2008 Sep 1;18(17):4853-8.

2. Lin TI, et al. Antimicrob Agents Chemother. 2009 Apr;53(4):1377-85.

3. Lenz O, et al. Antimicrob Agents Chemother. 2010 May;54(5):1878-87.

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