Silvestrol aglycone |CAS:960365-65-5 Probechem Biochemicals

Chemical Structure : Silvestrol aglycone

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Silvestrol aglycone

货号: PC-43429Not For Human Use, Lab Use Only.

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.

规格	价格	库存	数量
1 mg		Get quote
5 mg		Get quote
25 mg		Get quote

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生物&药学活性

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway; effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells; demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

物理化学性质&存储条件

分子量
分子式	C27H26O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 2,3,3a,8b-tetrahydro-1,6,8b-trihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-

参考文献

1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.

2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.

3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.

4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.