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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Eukaryotic Initiation Factor (eIF)-Silvestrol
Silvestrol

Chemical Structure : Silvestrol

CAS No.: 697235-38-4

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Silvestrol ((-)-Silvestrol)

货号: PC-43430Not For Human Use, Lab Use Only.

Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, and specific eukaryotic translation initiation factor 4A (eIF4A) inhibitor.
    Silvestrol induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway.
    Silvestrol effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells.
    Silvestrol demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.

    物理化学性质&存储条件

    分子量 654.66
    分子式 C34H38O13
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    DMSO; H2O: < 1 mg/mL
    Chemical Name/SMILES

    1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1R)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)-

    参考文献

    1. Lucas DM, et al. Blood. 2009 May 7;113(19):4656-66.

    2. Kim S, et al. Anticancer Res. 2007 Jul-Aug;27(4B):2175-83.

    3. Hwang BY, et al. J Org Chem. 2004 May 14;69(10):3350-8.

    4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1;18(17):4600-11.

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