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首页-小分子抑制剂&激动剂-Apoptosis-RIP kinase-Sibiriline
Sibiriline

Chemical Structure : Sibiriline

CAS No.: 1346526-26-8

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Sibiriline

货号: PC-70204Not For Human Use, Lab Use Only.

Sibiriline is a specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Sibiriline is a specific competitive RIPK1 inhibitor with IC50 of 1.03 uM, 100-fold less potent for RIPK3.
    Sibiriline inhibits both TNF-induced RIPK1-dependent necroptosis and RIPK1-dependent apoptosis in FADD-deficient Jurkat cells (EC50=1.2 uM).
    Sibiriline selectively inhibits necroptotic cell death induced by various death ligands in human or mouse cells while not protecting from caspase-dependent apoptosis.
    Sibiriline protects mice from concanavalin A-induced hepatitis.

    物理化学性质&存储条件

    分子量 210.236
    分子式 C13H10N2O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol

    参考文献

    1. Le Cann F, et al. FEBS J. 2017 Jul 17. doi: 10.1111/febs.14176.

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