Siastatin B

Chemical Structure : Siastatin B

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货号: PC-21646Not For Human Use, Lab Use Only.

Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases.

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生物&药学活性

Siastatin B is a potent and effective iminosugar inhibitor of diverse glycosidase classes, namely, sialidases, β-d-glucuronidases, and N-acetyl-glucosaminidases.
Siastatin B is a bacterial neuraminidase inhibitor isolated from Streptomyces culture.
Siastatin B also inhibits human cytosolic sialidase (Neuraminidase 2, NEU2).

物理化学性质&存储条件

分子量	218.21
分子式	C8H14N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S,4S,5R,6R)-6-acetamido-4,5-dihydroxypiperidine-3-carboxylic acid

参考文献

1. Nishimura Y, et al. J Antibiot (Tokyo). 1993 Dec;46(12):1883-9.

2. Rahman MM, et al. Biochem Biophys Rep. 2015 Sep 25;4:234-242.

3. Chen Y, et al. J Am Chem Soc. 2023 Dec 20. doi: 10.1021/jacs.3c04162.

Siastatin B

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Siastatin B

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