Setmelanotide (RM-493, BIM-22493) | MC4R agonist | Probechem Biochemicals

Chemical Structure : Setmelanotide

CAS No.: 920014-72-8

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Setmelanotide (RM-493, BIM-22493, IRC-022493)

货号: PC-45743Not For Human Use, Lab Use Only.

Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin-4 receptor (MC4R) agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥780	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote

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生物&药学活性

Setmelanotide (RM-493, BIM-22493, IRC-022493) is a peptide, non-selective melanocortin-4 receptor (MC4R) agonist with binding Ki of 3.9/10/2.1 for hMC1R/hMC3R/hMC4R, respectively.
Setmelanotide exhibits weak activity at MC5R (EC50>1 uM) and inactive at the mouse MC2R (EC50>10 uM).
Setmelanotide acutely improves glucose homeostasis, causes weight loss and improves hyperinsulinemia and fatty liver in diet induced obese mice.

物理化学性质&存储条件

分子量	1117.309
分子式	C49H68N18O9S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	50 mM in H2O
Chemical Name/SMILES	L-Cysteinamide, N2-acetyl-L-arginyl-L-cysteinyl-D-alanyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-, cyclic (2→8)-disulfide

参考文献

1. Kumar KG, et al. Peptides. 2009 Oct;30(10):1892-900.

2. Chen KY, et al. J Clin Endocrinol Metab. 2015 Apr;100(4):1639-45.

3. Bischof JM, et al. Br J Pharmacol. 2016 Sep;173(17):2614-21.

Setmelanotide (RM-493, BIM-22493, IRC-022493)

生物&药学活性

物理化学性质&存储条件

参考文献

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Setmelanotide (RM-493, BIM-22493, IRC-022493)

生物&药学活性

物理化学性质&存储条件

参考文献

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