欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-GPCR-Prostaglandin Receptor-Seratrodast
Seratrodast

Chemical Structure : Seratrodast

CAS No.: 112665-43-7

加入收藏

Seratrodast (AA2414, AA-2414)

货号: PC-23531Not For Human Use, Lab Use Only.

Seratrodast (AA2414) is a potent, specific thromboxane A2 (TXA2) receptor antagonist, competitively inhibits the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively, also inhibits ferroptosis.

规格 价格 库存 数量
25 mg ￥580 In stock
50 mg ￥880 In stock
100 mg ￥1380 In stock
250 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Seratrodast (AA2414) is a potent, specific thromboxane A2 (TXA2) receptor antagonist, competitively inhibits the contractile response to U-46619 in guinea pig tracheal and parenchymal strips and dog saphenous vein strips with pA2 values of 7.69, 8.29 and 6.79, respectively, also inhibits ferroptosis.
Seratrodast (AA2414) inhibits the contractile responses of guinea pig tracheal strip to PGD2, 9 alpha, 11 beta-PGF2 and PGF2 alpha with pA2 values of 7.20, 7.79 and 5.71, respectively.
Seratrodast (AA2414) inhibits ferroptosis by suppressing lipid peroxidation.
Seratrodast (AA2414) reduces lipid ROS production, modulates the systemic xc-/GSH/GPX4 axis, and inhibits JNK phosphorylation and p53 expression.
Seratrodast (AA2414) suppresses ferroptosis, but not apoptosis and necroptosis.
Seratrodast (AA2414) ameliorates the severity of renal ischemia-reperfusion injury in mice.

物理化学性质&存储条件

分子量 354.45
分子式 C22H26O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-Phenyl-7-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)heptanoic acid

参考文献

1. Matsumoto T, et al. Prostaglandins. 1993 Oct;46(4):301-18.

2. Fujimura M, et al. J Allergy Clin Immunol. 1991 Jan;87(1 Pt 1):23-7.

3. Tschuck J, et al. Cell Death Dis. 2024 Nov 22;15(11):853.

备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

联系我们 sales@probechem.com

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

  • *Product name:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Requested quantity:
  • *Country:
  • *Additional Information:

询单

  • *产品名称:
  • *姓名:
  • *邮箱:
  • *公司名称:
  • *询单数量:
  • *国籍:
  • 询单信息: