Serabelisib (INK1117,TAK-117) | p110α inhibitor Probechem Biochemicals

Chemical Structure : Serabelisib

CAS No.: 1268454-23-4

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Serabelisib (INK1117, TAK-117, TAK117, INK-1117)

货号: PC-42947Not For Human Use, Lab Use Only.

Serabelisib (INK1117,TAK-117) is a potent, selective PI3K p110α inhibitor with IC50 of 15 nM, displays >300-fold selectivity over p110β/γ/δ and mTOR.

规格	价格	库存
5 mg	￥580	In stock
10 mg	￥880	In stock
50 mg	￥1780	In stock
100 mg	￥2880	In stock
250 mg		Get quote

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生物&药学活性

Serabelisib (INK1117,TAK-117) is a potent, selective PI3K p110α inhibitor with IC50 of 15 nM, displays >300-fold selectivity over p110β/γ/δ and mTOR.
Serabelisib (INK1117,TAK-117) inhibits AKT phosphorylation and growth in PIK3CA mutant breast cancer cells with IC50 of 2 uM, significantly suppresses B cell proliferation driven by anti-IgM alone but not by anti-IgM plus IL-4.
Serabelisib (INK1117,TAK-117) abrogates immune checkpoint mediated proliferation in peripheral T-cell lymphoma combined with alisertib.

物理化学性质&存储条件

分子量	363.37
分子式	C19H17N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.4 mg/mL (Need ultrasonic or warming)
Chemical Name/SMILES	Methanone, [6-(2-amino-5-benzoxazolyl)imidazo[1,2-a]pyridin-3-yl]-4-morpholinyl-

参考文献

1. So L, et al. J Biol Chem. 2013 Feb 22;288(8):5718-31.

2. Juric D, et al. Clin Cancer Res. 2017 Sep 1;23(17):5015-5023.

3. Islam S, et al. Oncotarget. 2017 Nov 1;8(59):100326-100338.

4. Yea SS, et al. PLoS One. 2014 Jun 10;9(6):e99486.

Serabelisib (INK1117, TAK-117, TAK117, INK-1117)

生物&药学活性

物理化学性质&存储条件

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Serabelisib (INK1117, TAK-117, TAK117, INK-1117)

生物&药学活性

物理化学性质&存储条件

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