Sepimostat (FUT-187) | Multi-protease inhibitor | Probechem Biochemicals

Chemical Structure : Sepimostat

CAS No.: 103926-64-3

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Sepimostat (FUT-187, FUT187)

货号: PC-20173Not For Human Use, Lab Use Only.

Sepimostat (FUT-187) is a potent multi-protease inhibitor with IC50 of 0.097 uM for trypsin, 0.029 uM for pancreatic kallikrein, 0.61 uM for plasma kallikrein, 0.57uM for plasmin, 2.5 uM for thrombin, 20.4 uM for factor Xa and 6.4 uM for C1r.

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5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5480	In stock
50 mg	￥7580	In stock
100 mg		Get quote

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生物&药学活性

Sepimostat (FUT-187) is a potent multi-protease inhibitor with IC50 of 0.097 uM for trypsin, 0.029 uM for pancreatic kallikrein, 0.61 uM for plasma kallikrein, 0.57uM for plasmin, 2.5 uM for thrombin, 20.4 uM for factor Xa and 6.4 uM for C1r.
Sepimostat (FUT-187) acts as a noncompetitive inhibitor for factor XIIa and an uncompetitive inhibitor for C1s with Ki value of 0.021 and 0.18 uM, respectively.
Sepimostat (FUT-187) inhibits the kinin formation by glandular kallikrein in the rat plasma with IC50 of 0.024 uM.
Sepimostat (FUT-187) also inhibits the complement-mediated hemolyses in the classical and alternative pathways with IC50 of 0.17 and 3.5 uM, respectively.
Sepimostat (FUT-187) is a potent and selective inhibitor of trypsin-like serine proteases, and its inhibitory activities are stronger than those of camostat on glandular kallikrein, factor XIIa and C1s in complement pathway.

物理化学性质&存储条件

分子量	373.42
分子式	C21H19N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6-carbamimidoylnaphthalen-2-yl) 4-(4,5-dihydro-1H-imidazol-2-ylamino)benzoate

参考文献

1. Fuwa M, et al. Sci Rep. 2019 Dec 31;9(1):20409.

2. Zhigulin AS, et al. Eur J Pharmacol. 2023 Jan 5;938:175394.

3. Nakamura K, et al. Yakugaku Zasshi. 1995 Mar;115(3):201-12.

Sepimostat (FUT-187, FUT187)

生物&药学活性

物理化学性质&存储条件

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Sepimostat (FUT-187, FUT187)

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物理化学性质&存储条件

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