Sephin 1 |CAS:951441-04-6 Probechem Biochemicals

Chemical Structure : Sephin 1

CAS No.: 951441-04-6

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Sephin 1 (Icerguastat, NSC 65390, IFB-088)

货号: PC-62320Not For Human Use, Lab Use Only.

Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.

规格	价格	库存
10 mg	￥880	In stock
25 mg	￥1480	In stock
50 mg	￥2280	In stock
100 mg	￥3680	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

Sephin 1 (Icerguastat, NSC 65390) is a selective inhibitor of PPP1R15A that disrupts the PPP1R15A-PP1c complex but spares the related PPP1R15B-PP1c complex.
Sephin 1 prolongs eIF2α phosphorylation after stress, attenuates the expression of stress genes such as CHOP, and protects cells from cytotoxic ER stress; lacks any measurable α2-adrenergic agonist activity in a cell-based assay, in contrast to Guanabenz.
Sephin 1 safely prevents the motor, morphological, and molecular defects in mice.

物理化学性质&存储条件

分子量	196.64
分子式	C8H9ClN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-(2-Chlorobenzylidene)hydrazinecarboximidamide

参考文献

1. Das I, et al. Science. 2015 Apr 10;348(6231):239-42.

Sephin 1 (Icerguastat, NSC 65390, IFB-088)

生物&药学活性

物理化学性质&存储条件

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Sephin 1 (Icerguastat, NSC 65390, IFB-088)

生物&药学活性

物理化学性质&存储条件

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