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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Vitamin D Receptor (VDR)-Seocalcitol
Seocalcitol

Chemical Structure : Seocalcitol

CAS No.: 134404-52-7

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Seocalcitol (EB-1089)

货号: PC-45803Not For Human Use, Lab Use Only.

Seocalcitol is vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer..

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Seocalcitol is vitamin D3 analogue with potential antineoplastic activity. Seocalcitol binds to and activates the vitamin D receptor, a cytoplasmic polypeptide expressed in normal vitamin D responsive tissues, but also overexpressed in certain cancers including hepatocellular carcinoma and pancreatic cancer.

Liver Cancer

Phase 2 Clinical

物理化学性质&存储条件

分子量 454.6844
分子式 C30H46O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R,2E,4E)-6-ethyl-6-hydroxy-1-methyl-2,4-octadien-1-yl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1R,3S,5Z)-

参考文献

1. Wang K, et al. Histopathology. 2015 Sep;67(3):386-97.

2. Sharma K, et al. Autophagy. 2014;10(12):2346-61.

3. Bhatia V, et al. Mol Cancer Ther. 2009 Jul;8(7):1787-98.

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