Senaparib (IMP4297)

Chemical Structure : Senaparib

CAS No.: 1401682-78-7

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货号: PC-38373Not For Human Use, Lab Use Only.

Senaparib (IMP4297) is a novel highly potent and selective oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1580	In stock
25 mg	￥2780	In stock
50 mg	￥4780	In stock
100 mg		Get quote

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生物&药学活性

Senaparib (IMP4297) is a novel highly potent and selective, oral PARP1/2 inhibitor with IC50 of 6.27 nM/1.57 nM, respectively, exhibits strong antitumor activity.
Senaparib (IMP4297) has demonstrated 20-fold more potent than olaparib in vivo and showing strong antitumor activity in preclinical studies, IMP4297 is well-tolerated with significant anti-tumor activity in clinical investigations.

物理化学性质&存储条件

分子量	478.460
分子式	C24H20F2N6O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	5-fluoro-1-(4-fluoro-3-(4-(pyrimidin-2-yl)piperazine-1-carbonyl)benzyl)quinazoline-2,4(1H,3H)-dione

参考文献

1. Junning Cao, et al. 2019 ASCO Annual Meeting I.