Selurampanel |CAS:912574-69-7 Probechem Biochemicals

Chemical Structure : Selurampanel

CAS No.: 912574-69-7

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Selurampanel (BGG492, BGG-492)

货号: PC-61712Not For Human Use, Lab Use Only.

Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
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生物&药学活性

Selurampanel (BGG 492) is a selective, orally active and competitive AMPA receptor (AMPAR) antagonist with IC50 of 0.19 uM.
Selurampanel (BGG 492) displays >100-fold selectivity over NMDA and kainate receptors.
Selurampanel (BGG 492) demonstrates excellent oral potency against MES-induced generalized tonic-clonic seizures in rodents as well as significant activity in patients suffering from various forms of epilepsy.

物理化学性质&存储条件

分子量	377.418
分子式	C16H19N5O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(7-isopropyl-6-(1-methyl-1H-pyrazol-5-yl)-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)methanesulfonamide

参考文献

1. Orain D, et al. ChemMedChem. 2017 Feb 3;12(3):197-201.

2. Kasteleijn-Nolst Trenité D, et al. Epilepsia. 2015 Jun;56(6):924-32.

3. Faught E. Expert Opin Investig Drugs. 2014 Jan;23(1):107-13.

Selurampanel (BGG492, BGG-492)

生物&药学活性

物理化学性质&存储条件

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Selurampanel (BGG492, BGG-492)

生物&药学活性

物理化学性质&存储条件

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