Selpercatinib (LOXO-292) | RET inhibitor | Probechem Biochemicals

Chemical Structure : Selpercatinib

CAS No.: 2152628-33-4

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Selpercatinib (LOXO-292, LOXO292)

货号: PC-60209Not For Human Use, Lab Use Only.

Selpercatinib (LOXO-292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively.

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25 mg	￥1580	In stock
50 mg	￥2480	In stock
100 mg	￥3880	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Selpercatinib (LOXO-292, LOXO292) is a potent, selective, orally available RET kinase inhibitor with IC50 of 14.0 nM, 24.1 nM, and 530.7 nM for RET (WT), RET (V804M), and RET (G810R), respectively.
LOXO-292 displays >100-fold selectivity versus important off-targets.
LOXO-292 shows anti-tumor activty in the brain and periphery in RET-dependent tumor models in vivo.

物理化学性质&存储条件

分子量	525.613
分子式	C29H31N7O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(2-hydroxy-2-methylpropoxy)-4-(6-(6-((6-methoxypyridin-3-yl)methyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)pyridin-3-yl)pyrazolo[1,5-a]pyridine-3-carbonitrile

参考文献

1. Subbiah V, et al. Ann Oncol. 2018 Aug 1;29(8):1869-1876.

2. Cancer Discov. 2018 Aug;8(8):904-905.

Selpercatinib (LOXO-292, LOXO292)

生物&药学活性

物理化学性质&存储条件

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Selpercatinib (LOXO-292, LOXO292)

生物&药学活性

物理化学性质&存储条件

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