CKBA (Selovoxolone) | Th17 cell differentiation inhibitor, ACC1 inhibitor

Chemical Structure : Selovoxolone

加入收藏

Selovoxolone (CKBA)

货号: PC-27498Not For Human Use, Lab Use Only.

CKBA (Selovoxolone) is a small molecule inhibitor of Th17 cell differentiation, inhibits mouse and human Th17 cell differentiation with an IC50 of 3.28 and 3.61 μM, respectively, and directly targeted acetyl-CoA carboxylase 1 (ACC1), inhibits ACC1 activity in vitro with IC50 of 5.02 uM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

CKBA (Selovoxolone) is a small molecule inhibitor of Th17 cell differentiation, inhibits mouse and human Th17 cell differentiation with an IC50 of 3.28 and 3.61 μM, respectively, and directly targeted acetyl-CoA carboxylase 1 (ACC1), inhibits ACC1 activity in vitro with IC50 of 5.02 uM.
CKBA potently inhibits Th17 cell differentiation through blocking ACC1-mediated fatty acid synthesis.
CKBA inhibits fatty acid synthesis in HepG2 cells with IC50 of 0.28 uM.
CKBA ointment improves psoriasis-like skin inflammation in mice.

物理化学性质&存储条件

分子量	580.85
分子式	C37H56O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3α,4β)-3-[(Cyclohexylcarbonyl)oxy]-11-oxours-12-en-23-oic acid

参考文献

1. Patent CN119970750 A 2025-05-13.

2. Fangzhou Lou, et al. Br J Pharmacol. 2024 Apr;181(8):1290-1307.

Selovoxolone (CKBA)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Selovoxolone (CKBA)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.