Selinexor (KPT-330) | CRM1 inhibitor | Probechem Biochemicals

Chemical Structure : Selinexor

CAS No.: 1393477-72-9

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Selinexor (KPT-330, KPT330)

货号: PC-35581Not For Human Use, Lab Use Only.

Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1).

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10 mg	￥980	In stock
25 mg	￥1580	In stock
50 mg	￥2480	In stock
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生物&药学活性

Selinexor (KPT-330, KPT330) is a potent, orally available, selective inhibitor of nuclear export (SINE) targeting CRM1 (XPO1).
Selinexor demonstrates in vivo anti-leukaemic efficacy against T-ALL and acute myeloid leukaemia (AML) cells.
Selinexor triggers nuclear accumulation of multiple CRM1 cargo tumor suppressor proteins followed by growth arrest and apoptosis in MM cells, block c-Myc, Mcl-1, and NF-κB activity.
Selinexor (KPT-330, KPT330) induces proteasome-dependent CRM1 protein degradation, upregulates CRM1, p53-targeted, apoptosis-related, anti-inflammatory and stress-related gene transcripts in MM cells.

物理化学性质&存储条件

分子量	443.313
分子式	C17H11F6N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyrazinyl)hydrazide

参考文献

1. Tai YT, et al. Leukemia. 2014 Jan;28(1):155-65.

2. Etchin J, et al. Br J Haematol. 2013 Apr;161(1):117-27.

3. Azmi AS, et al. Gastroenterology. 2013 Feb;144(2):447-56.

4. Walker CJ, et al. Blood. 2013 Oct 24;122(17):3034-44.

Selinexor (KPT-330, KPT330)

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物理化学性质&存储条件

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Selinexor (KPT-330, KPT330)

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