Seletracetam | SV2A ligand | Probechem Biochemicals

Chemical Structure : Seletracetam

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Seletracetam (UCB 44212)

货号: PC-49726Not For Human Use, Lab Use Only.

Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy.

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生物&药学活性

Seletracetam (ucb 44212) is a high affinity for the synaptic vesicle protein 2A (SV2A) than levetiracetam with 10-fold, exhibits anticonvulsant properties in animal models of epilepsy.
Seletracetam (ucb 44212) reduced both the amplitude and repetitive firing of population spikes induced by a high K(+)/low Ca(2+) concentration fluid (HKLCF) in rat hippocampal slices.
Seletracetam (ucb 44212) also showed a potent anti-seizure activity in animal models mimicking partial-onset (kindled animals) and generalized epilepsy (audiogenic seizure susceptible mice and genetic absence epilepsy rats from Strasbourg (GAERS)).
Seletracetam (ucb 44212) also inhibited high-voltage-activated Ca2+ currents and intracellular Ca2+ increase in rat cortical neurons in vitro.
Seletracetam (ucb 44212) significantly reduced both the duration of paroxysmal depolarization shifts (PDSs) with IC50 of 241 nM, significantly reduced HVACCs in pyramidal neurons.

物理化学性质&存储条件

分子量	232.23
分子式	C10H14F2N2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-[(4S)-4-(2,2-difluorovinyl)-2-oxopyrrolidin-1-yl]butanamide

参考文献

1. Hamann M, et al. Eur J Pharmacol. 2008 Dec 28;601(1-3):99-102.

2. Martella G, et al. Epilepsia. 2009 Apr;50(4):702-10.

3. Matagne A, et al. Eur J Pharmacol. 2009 Jul 1;614(1-3):30-7.

Seletracetam (UCB 44212)

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物理化学性质&存储条件

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Seletracetam (UCB 44212)

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