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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-PPAR-Seladelpar
Seladelpar

Chemical Structure : Seladelpar

CAS No.: 851528-79-5

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Seladelpar (MBX8025, RWJ800025)

货号: PC-61150Not For Human Use, Lab Use Only.

Seladelpar (MBX-8025, RWJ800025) is a potent, selective, orally bioavailable PPAR-delta (PPARδ) agonist with EC50 of 2 nM, displays >750-fold selective over PPAR-α.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3280 In stock
100 mg ￥5280 In stock
250 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Seladelpar (MBX-8025, RWJ800025) is a potent, selective, orally bioavailable PPAR-delta (PPARδ) agonist  with EC50 of 2 nM, displays >750-fold selective over PPAR-α.
Seladelpar (MBX-8025) exhibits anti-cholestatic effects and potential for the treatment of dyslipidemia, metabolic syndrome, type 2 diabetes, and non-alcoholic steatohepatitis (NASH).

物理化学性质&存储条件

分子量 444.465
分子式 C21H23F3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R)-2-(4-((2-ethoxy-3-(4-(trifluoromethyl)phenoxy)propyl)thio)-2-methylphenoxy)acetic acid

参考文献

1. Bays HE, et al. J Clin Endocrinol Metab. 2011 Sep;96(9):2889-97.

2. Jones D, et al. Lancet Gastroenterol Hepatol. 2017 Oct;2(10):716-726.

3. Choi YJ, et al. Atherosclerosis. 2012 Feb;220(2):470-6.

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