Seclidemstat |CAS:1423715-37-0 Probechem Biochemicals

Chemical Structure : Seclidemstat

CAS No.: 1423715-37-0

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货号: PC-61398Not For Human Use, Lab Use Only.

Seclidemstat (SP-2577, SP2577) is a potent, selecftive and reversible LSD1 inhibitor with IC50 of 13 nM in biochemical assays.

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Seclidemstat (SP-2577, SP2577) is a potent, selecftive and reversible LSD1 inhibitor with IC50 of 13 nM in biochemical assays.

SP-2577 inhibits SWI/SNF-mutation-dependent tumor cell proliferation with IC50 of 0.529 uM for COV434 (SMARCA4).

SP-2577 promotes ERV expression, activates the dsRNA-induced IFN pathway, and enhances T-cell infiltration in SCCOHT.

SP-2577 also promotes PD-L1 expression, and thus can potentially overcome resistance to anti-PD-1 therapy in SCCOHT.

分子量	450.938
分子式	C20H23ClN4O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N'-[(1E)-1-(5-chloro-2-hydroxyphenyl)ethylidene]-3-(4-methylpiperazine-1-sulfonyl)benzohydrazide

1. Patent WO/2017/004519 A1.
2. Soldi R, et al. PLoS One. 2020 Jul 10;15(7):e0235705.