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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Savirin
Savirin

Chemical Structure : Savirin

CAS No.: 2163006-04-8

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Savirin (S. aureus virulence inhibitor)

货号: PC-20319Not For Human Use, Lab Use Only.

Savirin (S. aureus virulence inhibitor) is a small molecule inhibitor inhibiting agr quorum sensing in S. aureus by blocking the transcriptional function of AgrA.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Savirin (S. aureus virulence inhibitor) is a small molecule inhibitor inhibiting agr quorum sensing in S. aureus by blocking the transcriptional function of AgrA.
    Savirin inhibits RNA III levels in S. aureus, but not S. epidermidis, without affecting agr-independent growth.
    Savirin (5 ug/mL) inhibited agr::P3 activation in reporter strains of all agr alleles, inhibits both AIP1-induced RNAIII and RNAIII produced at a longer time point without addition of exogenous AIP1 with no effect on exponential phase growth.
    Savirin inhibits agr-regulated gene transcription and secreted virulence factor production.
    Savirin inhibits AgrA-dependent transcription in clinical isolates.
    Savirin treatment in vivo attenuates tissue injury and promotes agr but not Δagr bacterial clearance, promotes agr-dependent host defense in vivo and in vitro.

    物理化学性质&存储条件

    分子量 368.41
    分子式 C18H16N4O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-((4-isopropylphenyl)sulfonyl)-[1,2,3]triazolo[1,5-a]quinazolin-5(1H)-one

    参考文献

    1. Sully EK, et al. PLoS Pathog. 2014 Jun 12;10(6):e1004174.

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