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首页-小分子抑制剂&激动剂-GPCR-Neurokinin Receptor-Saredutant
Saredutant

Chemical Structure : Saredutant

CAS No.: 142001-63-6

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Saredutant (SR-48968, SR48968)

货号: PC-70189Not For Human Use, Lab Use Only.

Saredutant (SR48968) is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Saredutant (SR48968) is a potent and selective non-peptide antagonist of the neurokinin A (NK2) receptor.
    Saredutant (SR48968) displays >1,000-fold selectivity over NK3 receptor, and does not affect the effects of bradykinin, angiotensin or bombesin.
    Saredutant (SR48968) inhibits the bronchoconstriction induced by neurokinin A in guinea pigs>
    Saredutant (SR48968) inhibits the cholinergic response of the isolated guinea-pig main bronchus to electrical field stimulation.

    物理化学性质&存储条件

    分子量 552.5345
    分子式 C31H35Cl2N3O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-[(2S)-4-[4-(Acetylamino)-4-phenyl-1-piperidinyl]-2-(3,4-dichlorophenyl)butyl]-N-methylbenzamide

    参考文献

    1. Emonds-Alt X, et al. Life Sci. 1992;50(15):PL101-6.

    2. Martin CA, et al. Eur J Pharmacol. 1993 Oct 26;243(3):309-12.

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