Saracatinib (AZD0530) | Src/Abl inhibitor | Probechem Biochemicals

Chemical Structure : Saracatinib

CAS No.: 379231-04-6

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Saracatinib (AZD0530, AZD-0530)

货号: PC-42475Not For Human Use, Lab Use Only.

Saracatinib (AZD0530) is a potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30 nM for c-Src, Yes, Lck and Abl, respectively.

规格	价格	库存
25 mg	￥780	In stock
50 mg	￥1280	In stock
100 mg	￥2180	In stock
250 mg	￥3580	In stock
1 g		Get quote

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生物&药学活性

Saracatinib (AZD0530) is a potent, highly selective, orally available, dual Src/Abl kinase inhibitor with IC50 of 2.7, 4, 4 and 30 nM for c-Src, Yes, Lck and Abl, respectively.
Saracatinib (AZD0530) displays high selectivity over a range of kinases (Csk, VEGFR-2, Flt-4, EGFR, and PDGFR).
Saracatinib (AZD0530) exhibits potent inhibition of tumor growth in a c-Src-transfected 3T3-fibroblast xenograft model in vivo.

物理化学性质&存储条件

分子量	542.0265
分子式	C27H32ClN5O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	4-Quinazolinamine, N-(5-chloro-1,3-benzodioxol-4-yl)-7-[2-(4-methyl-1-piperazinyl)ethoxy]-5-[(tetrahydro-2H-pyran-4-yl)oxy]-

参考文献

1. Hennequin LF, et al. J Med Chem. 2006 Nov 2;49(22):6465-88.

2. Herynk MH, et al. Mol Cancer Ther. 2006 Dec;5(12):3023-31.

3. Chang YM, et al. Oncogene. 2008 Oct 23;27(49):6365-75.

4. Gwanmesia PM, et al. BMC Cancer. 2009 Feb 13;9:53.

Saracatinib (AZD0530, AZD-0530)

生物&药学活性

物理化学性质&存储条件

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Saracatinib (AZD0530, AZD-0530)

生物&药学活性

物理化学性质&存储条件

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