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Saquinavir

Chemical Structure : Saquinavir

CAS No.: 127779-20-8

Saquinavir (Ro 31-8959, Ro31-8959)

货号: PC-45133Not For Human Use, Lab Use Only.

Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Saquinavir (Ro 31-8959) is a potent and selective inhibitor of HIV-1 protease with IC50 of 0.5-6 nM in cell assays.
Saquinavir (Ro 31-8959) binds to the active site of the viral protease and prevents cleavage of viral polyproteins, preventing maturation of the virus; inhibits both HIV-1 and HIV-2 proteases.
Saquinavir (Ro 31-8959) is used to treat or prevent HIV/AIDS.

物理化学性质&存储条件

分子量 670.8408
分子式 C38H50N6O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Butanediamide, N1-[(1S,2R)-3-[(3S,4aS,8aS)-3-[[(1,1-dimethylethyl)amino]carbonyl]octahydro-2(1H)-isoquinolinyl]-2-hydroxy-1-(phenylmethyl)propyl]-2-[(2-quinolinylcarbonyl)amino]-, (2S)-

参考文献

1. Martin JA, et al. Biochem Biophys Res Commun. 1991 Apr 15;176(1):180-8.

2. Craig JC, et al. Antiviral Res. 1991 Dec;16(4):295-305.

3. Kräusslich HG. J Virol. 1992 Jan;66(1):567-72.

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