Sappanchalcone

Chemical Structure : Sappanchalcone

CAS No.: 94344-54-4

加入收藏

货号: PC-27328Not For Human Use, Lab Use Only.

Sappanchalcone is a flavonoid isolated from Caesalpinia sappan L, a potent low-toxicity Fibroblast activation protein α (FAPα) inhibitor with SPR KD of 3.88 uM.

规格	价格	库存
5 mg	￥3280	In stock
10 mg	￥5280	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Sappanchalcone is a flavonoid isolated from Caesalpinia sappan L, a potent low-toxicity Fibroblast activation protein α (FAPα) inhibitor with SPR KD of 3.88 uM.
Sappanchalcone not only inhibits FAPα enzymatic activity but also effectively downregulates its protein expression under fibrotic conditions.
Sappanchalcone displays inhibition of LX -2 cell proliferation, effectively inhibits the migration and invasion of activated hepatic stellate cells (aHSCs), demonstrating excellent anti -fibrotic potential.
Sappanchalcone suppresses hepatic stellate cell activation through inhibition of the FAPα-PI3K-AKT signaling pathway.
Sappanchalcone markedly attenuates fibrosis progression and improves liver function in multiple liver fibrosis models using male mice.
Sappanchalcone demonstrates significant upregulation of α -SMA and FAPα proteins in the BDL model, both of which are effectively downregulated by Sappanchalcone.

物理化学性质&存储条件

分子量	286.28
分子式	C16H14O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-3-(3,4-Dihydroxyphenyl)-1-(4-hydroxy-2-methoxyphenyl)prop-2-en-1-one

参考文献

1. Wenze Zhang, et al. Nature Communications (2026)

2. Seo HW, et al. Chem Biol Interact. 2020;327:109185.

Sappanchalcone

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Sappanchalcone

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.