Sanofi-14h | SGK3 inhibitor | Probechem Biochemicals

Chemical Structure : Sanofi-14h

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Sanofi-14h (SGK3 inhibitor 14h)

货号: PC-21338Not For Human Use, Lab Use Only.

Sanofi-14h is a selective inhibitor of the AGC family kinase SGK3, blocks DMXAA-stimulated IRF3-promoter activity with IC50 of 1.73 uM, inhibits IFNβ production under STING stimulation.

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生物&药学活性

Sanofi-14h is a selective inhibitor of the AGC family kinase SGK3, blocks DMXAA-stimulated IRF3-promoter activity with IC50 of 1.73 uM, inhibits IFNβ production under STING stimulation.
Sanofi-14h not only shows higher activity toward SGK3 as compared with SGK1 but also has significant activity against kinases such as S6K1 (P70S6K1) and MLK3.
Sanofi-14h blocks IFNβ mRNA induction in a dose-dependent manner with EC50 of 0.5-1 uM in RAW264.7 cells.
Sanofi-14h blocks the phosphorylation of TBK1 and IRF3, along with the dimerization and nuclear translocation of IRF3 following treatment with a STING agonist, thus blocking IFNβ gene induction.
Sanofi-14h blocks the recruitment of TBK1 and IRF3 into the STING complex. Sanofi-14h blocks IFNβ gene induction induced by STING ligands and HSV-1. Sanofi-14h blocks the STING-induced TBK1-IRF3 signaling cascade.
Sanofi-14h blocks DMXAA-stimulated interferon and ISG gene expression in macrophages.
Sanofi-14h disrupts inducible TBK1-STING interaction.
Sanofi-14h inhibits phosphorylation of TBK1 through an unknown mechanism preventing STING and IRF3 phosphorylation, dimerization, and nuclear translocation in the presence of 2′3′-cGAMP and DMXAA.

物理化学性质&存储条件

分子量	435.28
分子式	C17H12Cl2N6O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-amino-1H-pyrazolo[3,4-b]pyrazin-6-yl)phenyl)-2,5-dichlorobenzenesulfonamide

参考文献

1. Towhid ST, et al. Cell Physiol Biochem. 2013;32(4):838-48.

Sanofi-14h (SGK3 inhibitor 14h)

生物&药学活性

物理化学性质&存储条件

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Sanofi-14h (SGK3 inhibitor 14h)

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物理化学性质&存储条件

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