Samatasvir | HCV NS5A inhibitor | Probechem Biochemicals

Chemical Structure : Samatasvir

CAS No.: 1312547-19-5

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Samatasvir (IDX-719, MK-1894, IDX719, MK1894)

货号: PC-61524Not For Human Use, Lab Use Only.

Samatasvir (IDX719) is a highly potent, selective inhibitor of HCV NS5A that effectively inhibits HCV genotype 1-5 replicons with EC50 of 2-24 pM.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
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100 mg		Get quote

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生物&药学活性

Samatasvir (IDX719) is a highly potent, selective inhibitor of HCV NS5A that effectively inhibits HCV genotype 1-5 replicons with EC50 of 2-24 pM.
Samatasvir also retains full activity in the presence of HIV and hepatitis B virus (HBV) antivirals.
Samatasvir demonstrates an overall additive effect when combined with IFN-α, ribavirin, representative HCV protease, and nonnucleoside polymerase inhibitors or the nucleotide prodrug IDX184.

物理化学性质&存储条件

分子量	885.062
分子式	C47H48N8O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl N-[(1R)-2-[(2S)-2-[5-[4-[6-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methylbutanoyl]pyrrolidin-2-yl]-3H-benzimidazol-5-yl]thieno[3,2-b]thiophen-3-yl]phenyl]-1H-imidazol-2-yl]pyrrolidin-1-yl]-2-oxo-1-phenylethyl]carbamate

参考文献

1. Bilello JP, et al. Antimicrob Agents Chemother. 2014 Aug;58(8):4431-42.

2. Vince B, et al. J Hepatol. 2014 May;60(5):920-7.

Samatasvir (IDX-719, MK-1894, IDX719, MK1894)

生物&药学活性

物理化学性质&存储条件

参考文献

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Samatasvir (IDX-719, MK-1894, IDX719, MK1894)

生物&药学活性

物理化学性质&存储条件

参考文献

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