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首页-小分子抑制剂&激动剂-Epigenetics-Histone Methyltransferase (HMTase)-Salvianolic acid C
Salvianolic acid C

Chemical Structure : Salvianolic acid C

CAS No.: 115841-09-3

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Salvianolic acid C (YTHDF1 inhibitor SAC)

货号: PC-21348Not For Human Use, Lab Use Only.

Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1.

规格 价格 库存 数量
5 mg ￥980 In stock
10 mg ￥1480 In stock
25 mg ￥2380 In stock
50 mg ￥3980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1.
Salvianolic acid C shows issociation constant (KD) against YTHDF1 with 6.3 and 5.3 μM through individual isothermal titration calorimetry (ITC) assay and microscale thermophoresis (MST), respectively.
Salvianolic acid C dissolves YTHDF1 condensates and counteracts hyperactive YTHDF1 in neurons.
Salvianolic acid C reverses neurodevelopmental deficits in fragile X syndrome (FXS) forebrain organoids.

物理化学性质&存储条件

分子量 492.44
分子式 C26H20O10
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(R,E)-3-(3,4-Dihydroxyphenyl)-2-((3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)oxy)propanoic acid

参考文献

1. Zou Z, et al. Mol Cell. 2023 Nov 2:S1097-2765(23)00865-1.

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