Chemical Structure : Salvianolic acid C
CAS No.: 115841-09-3
货号: PC-21348Not For Human Use, Lab Use Only.
Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥980 | In stock | |
10 mg | ¥1480 | In stock | |
25 mg | ¥2380 | In stock | |
50 mg | ¥3980 | In stock | |
100 mg | Get quote |
大包装,大折扣!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Salvianolic acid C (YTHDF1 inhibitor SAC) is a selective, competitive small molecule inhibitor of m6A reader YTHDF1 with IC50 of 1.4 uM in in vitro binding assays, shows weaker activity against YTHDF2 (IC50=29 uM), inhibits YTHDF1 and suppresses oligomerization of YTHDF1.
Salvianolic acid C shows issociation constant (KD) against YTHDF1 with 6.3 and 5.3 μM through individual isothermal titration calorimetry (ITC) assay and microscale thermophoresis (MST), respectively.
Salvianolic acid C dissolves YTHDF1 condensates and counteracts hyperactive YTHDF1 in neurons.
Salvianolic acid C reverses neurodevelopmental deficits in fragile X syndrome (FXS) forebrain organoids.
分子量 | 492.44 | |
分子式 | C26H20O10 | |
外观性状 | Solid | |
储存条件 |
|
|
Solubility |
10 mM in DMSO |
|
Chemical Name/SMILES |
(R,E)-3-(3,4-Dihydroxyphenyl)-2-((3-(2-(3,4-dihydroxyphenyl)-7-hydroxybenzofuran-4-yl)acryloyl)oxy)propanoic acid |
1. Zou Z, et al. Mol Cell. 2023 Nov 2:S1097-2765(23)00865-1.
备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright