Salvage-1 | α4β2 nAChRs PAM | Probechem Biochemicals

Chemical Structure : Salvage-1

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Salvage-1 (Salvage 1, Salvage1)

货号: PC-26888Not For Human Use, Lab Use Only.

Salvage-1 is a selective, positive allosteric modulator (PAM) of α4β2 nAChRs, demonstrates potent antiarrhythmic efficacy.

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生物&药学活性

Salvage-1 is a selective, positive allosteric modulator (PAM) of α4β2 nAChRs, demonstrates potent antiarrhythmic efficacy.
Salvage-1 suppresses re-entry through α4β2 nAChR-mediated enhancement of myocardial excitability and conductivity.
Salvage-1 selectively stabilizes the α4 subunit (CHRNA4), with minimal effect on the β2 subunit (CHRNB2), also shows weak inhibition of key cardiac ion channels, Cav1.2 and Nav1.5.
Salvage-1 selectively potentiates α4β2 nAChRs by interacting with residues Phe312 and Phe316 of α4 subunit, thereby stabilizing the receptor in its open-channel state.
Salvage-1 demonstrates marked antiarrhythmic efficacy in rodent models of fatal ventricular tachyarrhythmias (FVTs).
Salvage-1 demonstrates superior efficacy compared to lidocaine in both porcine and human models of FVTs.

物理化学性质&存储条件

分子量	325.37
分子式	C18H19N3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-methoxy-1H-indol-3-yl)-N-(2-nitrobenzyl)ethan-1-amine

参考文献

1. Xie D, et al. Eur Heart J. 2026 May 18:ehag293.

Salvage-1 (Salvage 1, Salvage1)

生物&药学活性

物理化学性质&存储条件

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Salvage-1 (Salvage 1, Salvage1)

生物&药学活性

物理化学性质&存储条件

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