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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-SalA-VS-08
SalA-VS-08

Chemical Structure : SalA-VS-08

CAS No.: 2439152-14-2

SalA-VS-08

货号: PC-22909Not For Human Use, Lab Use Only.

SalA-VS-08 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 68.5 nM and EC50 of 854 nM, shows G protein-biased KOR agonist activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SalA-VS-08 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 68.5 nM and EC50 of 854 nM, shows G protein-biased KOR agonist activity.

物理化学性质&存储条件

分子量 396.47
分子式 C22H25FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

4'-(cyclopropylmethyl)-1-(3-fluorobenzoyl)-2'-methyl-4'H-spiro[piperidine-4,7'-pyrazolo[1,5-a]pyrimidin]-5'(6'H)-one

参考文献

1. Kristina Puls, et al. J Med Chem. 2024 Aug 1. doi: 10.1021/acs.jmedchem.4c00590.

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