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首页-小分子抑制剂&激动剂-GPCR-Opioid Receptor-SalA-VS-07
SalA-VS-07

Chemical Structure : SalA-VS-07

CAS No.: 2445895-33-8

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SalA-VS-07

货号: PC-22908Not For Human Use, Lab Use Only.

SalA-VS-07 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 423 nM and EC50 of 181 nM, shows G protein-biased KOR agonist activity.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SalA-VS-07 is a potent, highly selective kappa-opioid receptor (KOR) agonist with Ki of 423 nM and EC50 of 181 nM, shows G protein-biased KOR agonist activity.

物理化学性质&存储条件

分子量 412.92
分子式 C22H25ClN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(4-chlorobenzoyl)-4'-(cyclopropylmethyl)-2'-methyl-4'H-spiro[piperidine-4,7'-pyrazolo[1,5-a]pyrimidin]-5'(6'H)-one

参考文献

1. Kristina Puls, et al. J Med Chem. 2024 Aug 1. doi: 10.1021/acs.jmedchem.4c00590.

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