Saframycin A |CAS:66082-27-7 Probechem Biochemicals

Chemical Structure : Saframycin A

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Saframycin A (NSC 325663)

货号: PC-70241Not For Human Use, Lab Use Only.

Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.

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生物&药学活性

Saframycin A is a heterocyclic quinone antibiotic that inhibits RNA synthesis in vivo and in vitro.
Saframycin A shows potent antiproliferative effects in leukemia- and tumor-derived cells.
Saframycin A induces nuclear translocation of GAPDH in cancer cells.

物理化学性质&存储条件

分子量	562.579
分子式	C29H30N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-[[(6S,7R,9R,14aS,15R)-7-Cyano-1,5,6,7,9,10,13,14,14a,15-decahydro-2,11-dimethoxy-3,12,16-trimethyl-1,4,10,13-tetraoxo-6,15-imino-4H-isoquino[3,2-b][3]benzazocin-9-yl]methyl]-2-oxopropanamide

参考文献

1. Xing C, et al. Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):5862-6.

2. Ishiguro K, et al. Biochemistry. 1978 Jun 27;17(13):2545-50.

3. Spencer JR, et al. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4884-8.

Saframycin A (NSC 325663)

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物理化学性质&存储条件

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Saframycin A (NSC 325663)

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物理化学性质&存储条件

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