Safotibant (LF22-0542)

Chemical Structure : Safotibant

加入收藏

货号: PC-26634Not For Human Use, Lab Use Only.

Safotibant (LF22-0542) is a potent, selective nonpeptidic antagonist of kinin B1 receptor (BKB1R, B1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

Safotibant (LF22-0542) is a potent, selective nonpeptidic antagonist of kinin B1 receptor (BKB1R, B1R), with Ki of 0.35 and 6.5 nM, for human and mouse BKB1R, respectively.
Safotibant (LF22-0542) shows no affinity for the human B2 receptor.
Safotibant (LF22-0542) is a competitive B1 receptor antagonist and elicited significant antinociceptive actions in the mouse acetic acid-induced writhing assay.
Safotibant (LF22-0542) alleviated thermal hypersensitivity in both acute (carrageenan) and persistent inflammatory (complete Freund's adjuvant) pain models in rats.

物理化学性质&存储条件

分子量	502.63
分子式	C25H34N4O5S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4,5-Dihydro-1H-imidazol-2-yl)benzyl)-2-(2-(4-methoxy-N,2,6-trimethylphenylsulfonamido)ethoxy)-N-methylacetamide

参考文献

1. Porreca F, et al. J Pharmacol Exp Ther. 2006 Jul;318(1):195-205.