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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Sphingosine kinase (SphK)-Safingol
Safingol

Chemical Structure : Safingol

CAS No.: 15639-50-6

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Safingol (L-threo-dihydrosphingosine)

货号: PC-23349Not For Human Use, Lab Use Only.

Safingol (L-threo-dihydrosphingosine) is a putative inhibitor of sphingosine kinase (SphK) and PKCalpha (PKCα), suppresses growth of human oral squamous cell carcinoma (SCC) cells, significantly inhibits PKC isoforms.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Safingol (L-threo-dihydrosphingosine) is a putative inhibitor of sphingosine kinase (SphK) and PKCalpha (PKCα), suppresses growth of human oral squamous cell carcinoma (SCC) cells, significantly inhibits PKC isoforms.

物理化学性质&存储条件

分子量 301.52
分子式 C18H39NO2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2S,3S)-2-aminooctadecane-1,3-diol

参考文献

1. Tsukamoto S, et al. Mol Cancer Ther. 2015 Oct;14(10):2303-12.

2. Dickson MA, et al. Clin Cancer Res. 2011 Apr 15;17(8):2484-92.

3. Coward J, et al. Autophagy. 2009 Feb;5(2):184-93.

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