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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Monoamine Oxidase (MAO)-Safinamide
Safinamide

Chemical Structure : Safinamide

CAS No.: 133865-89-1

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Safinamide (EMD1195686, FCE 26743)

货号: PC-45946Not For Human Use, Lab Use Only.

Safinamide (EMD1195686, FCE 26743) is a potent and selective inhibitor of monoamine oxidase B (MAO-B) with IC50 of 98 nM.

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25 mg ￥1280 In stock
50 mg ￥2180 In stock
100 mg ￥3580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Safinamide (EMD1195686, FCE 26743) is a potent and selective inhibitor of monoamine oxidase B (MAO-B) with IC50 of 98 nM.
Safinamide displays >5,000-fold selectivity over MAO-A.
Safinamide also inhibits glutamate release and dopamine reuptake, inhibits voltage-dependent Na+ and Ca2+ channels.
Safinamide is used for treatment ofParkinson's disease.

物理化学性质&存储条件

分子量 302.3434
分子式 C17H19FN2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

Propanamide, 2-[[[4-[(3-fluorophenyl)methoxy]phenyl]methyl]amino]-, (2S)-

参考文献

1. Leonetti F, et al. J Med Chem. 2007 Oct 4;50(20):4909-16.

2. Strolin Benedetti MS, et al. J Pharm Pharmacol. 1994 Oct;46(10):814-9.

3. Caccia C, et al. Neurology. 2006 Oct 10;67(7 Suppl 2):S18-23.

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