Safimaltib (JNJ-67856633)

Chemical Structure : Safimaltib

CAS No.: 2230273-76-2

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货号: PC-73444Not For Human Use, Lab Use Only.

Safimaltib (JNJ-67856633) is a potent, selective, allosteric inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) protease activity.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg	￥5580	In stock
250 mg		Get quote

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生物&药学活性

Safimaltib (JNJ-67856633) is a potent, selective, allosteric inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) protease activity.
Safimaltib (JNJ-67856633) inhibits proliferation of activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL) cell lines bearing CD79b or CARD11 mutations as well as models mimicking resistance to covalent BTK inhibitors.
JNJ-67856633 showed activity in organoid cultures derived from ABC-DLBCL patients.
JNJ-67856633 leads to potent in vivo pharmacodynamic shutdown in CD79b- as well as CARD11-mutant ABC-DLBCL models as measured by serum IL10 or uncleaved BCL10 levels in tumors.
JNJ-67856633 exhibits potent tumor growth inhibition in two human DLBCL xenograft models, OCI Ly3 and OCI Ly10.

物理化学性质&存储条件

分子量	467.331
分子式	C20H11F6N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(1-oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide

参考文献

1. Ulrike Philippar, et al. Cancer Res (2020) 80 (16_Supplement): 5690.