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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Bacterial-Saeamid-1
Saeamid-1

Chemical Structure : Saeamid-1

CAS No.: 902939-87-1

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Saeamid-1

货号: PC-27434Not For Human Use, Lab Use Only.

Saeamid-1 is a potential antivirulence compound and SaeS-targeting antagonist against methicillin-resistant Staphylococcus aureus (MRSA), reduces hemolytic activity and biofilm biomass while having only limited effects on MRSA growth.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Saeamid-1 is a potential antivirulence compound and SaeS-targeting antagonist against methicillin-resistant Staphylococcus aureus (MRSA), reduces hemolytic activity and biofilm biomass while having only limited effects on MRSA growth.
Saeamid-1 decreases hemolytic activity and biofilm biomass in MRSA reference strain USA300.
SaeS is a 351 amino acid membrane-associated histidine kinase that functions as a key sensor protein in the SaeRS two-component system of S. aureus.

物理化学性质&存储条件

分子量 443.29
分子式 C20H12BrFN2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N(4-bromo-2-fluorophenyl)-11-oxo-10,11-dihydrodibenzo[b,f][1,4]thiazepine-8-carboxamide

参考文献

1. Jiahao Yao, et al. Front Cell Infect Microbiol. 2026 Jul 8:16:1867130.

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