SZU-106 | TLR7 agonist | Probechem Biochemicals

Chemical Structure : SZU-106

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SZU-106 (SZU106)

货号: PC-49146Not For Human Use, Lab Use Only.

SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway.

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生物&药学活性

SZU-106 is a small molecule TLR7 agonist, selectively activates TLR7 and increases the expression of SEAP by activating the NF-κB pathway.
SZU-106 (0.5-10 μM) increased the release of interferon (IFN)-γ and IL-6 in a dose-dependent manner after 24 h of treatment in mouse splenic lymphocytes.
SZU-106 with a pegylated linker could produce a novel whole-tumor-cell vaccine, which induced immune-activating responses in both in vitro and in vivo experiments.

物理化学性质&存储条件

分子量	603.633
分子式	C27H37N7O9
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-((6-amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)phenyl)-3,6-dioxo-10,13-dioxa-2,7-diazahexadecan-16-oic acid

参考文献

1. Huju Chi, et al. Cells. 2022 Jun 21;11(13):1986.

SZU-106 (SZU106)

生物&药学活性

物理化学性质&存储条件

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SZU-106 (SZU106)

生物&药学活性

物理化学性质&存储条件

参考文献

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