SZU-101 | TLR7 agonist | Probechem Biochemicals

Chemical Structure : SZU-101

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SZU-101 (SZU101)

货号: PC-49145Not For Human Use, Lab Use Only.

SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling.

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100 mg		Get quote

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生物&药学活性

SZU101 is a small molecule TLR7 agonist that directly activates, induces reporter activity (23-fold) in a TLR7-NF-kB reporter system expressed in HEK-293 cells TLR7 signalling.
SZU-101 activated dendritic cells, B cells and T cells and induced cytokine production but did not directly affect tumour cells.
SZU-101 in combination with doxorubicin improves survival and induces durable tumouricidal effects in a murine model of T cell lymphoma.
Intratumoral administration of SZU101 can change the tumor microenvironment and delay distant tumor growth.
SZU101 significantly suppressed PRRSV infection in primary porcine alveolar macrophages (PAMs) in a dose-dependent manner.
SZU101 enhanced the humoral and cell-mediated immune responses against PRRSV antigens in mice.

物理化学性质&存储条件

分子量	444.448
分子式	C20H24N6O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-((4-((6-Amino-8-hydroxy-2-(2-methoxyethoxy)-9H-purin-9-yl)methyl)benzyl)amino)-4-oxobutanoic acid

参考文献

1. Diao Y, et al. Oncol Rep. 2016 Feb;35(2):793-800.

2. Du Y, et al. Antiviral Res. 2016 Jul;131:9-18.

SZU-101 (SZU101)

生物&药学活性

物理化学性质&存储条件

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SZU-101 (SZU101)

生物&药学活性

物理化学性质&存储条件

参考文献

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