SZ0232 (SZ-0232)

Chemical Structure : SZ0232

CAS No.: 924851-91-2

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货号: PC-38642Not For Human Use, Lab Use Only.

SZ0232 is a small molecule mPGES-2 (microsomal prostaglandin E synthase-2) inhibitor with IC50 of <1 uM, exhibits beneficial effects on modulating β-cell function and glucose metabolism both in vitro and in vivo.

规格	价格	库存
5 mg	￥2180	In stock
10 mg	￥3580	In stock
25 mg	￥5580	In stock
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100 mg		Get quote

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生物&药学活性

SZ0232 is a small molecule mPGES-2 (microsomal prostaglandin E synthase-2) inhibitor with IC50 of <1 uM, exhibits beneficial effects on modulating β-cell function and glucose metabolism both in vitro and in vivo.
SZ0232 effectively reduced PGE2 production and increase insulin release in vitro, increased insulin secretion induced by SZ0232 only occurred in response to high-glucose stimulation in
isolated islets, while having no effect on basal insulin secretion.
SZ0232 also exhibited a protective effect on the development of diabetes with better glucose tolerance and β-cell function compared to placebo treatment being noted in vivo.
SZ0232 protects against β-cell dysfunction and diabetes, similar to mPGES-2 deletion.

物理化学性质&存储条件

分子量	520.561
分子式	C22H28N6O7S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(3,4-bis(2-ureidoethoxy)phenyl)-4-(2-oxopyrrolidin-1-yl)benzenesulfonamide

参考文献

1. Dandan Zhong, et al. Nat Metab. 2022 Feb;4(2):269-283.

SZ0232 (SZ-0232)

生物&药学活性

物理化学性质&存储条件

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SZ0232 (SZ-0232)

生物&药学活性

物理化学性质&存储条件

参考文献

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