SYSUP007

Chemical Structure : SYSUP007

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货号: PC-25412Not For Human Use, Lab Use Only.

SYSUP007 is a derivative of the FTO inhibitor rhein, and HDAC and SGK1 inhibitor, inhibits the proliferation of human GBM cells.

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生物&药学活性

SYSUP007 is a derivative of the FTO inhibitor rhein, and HDAC and SGK1 inhibitor, inhibits the proliferation of human GBM cells.
SYSUP007 inhibits the survival of all three cell lines in a dose-dependent manner, with IC50 values of 5.5 μM, 8 μM and 7 μM, in T98G, U87, U251 cells, respectively.
SYSUP007 inhibits the migration of human GBM cells.
SYSUP007 inhibited the activity of HDAC and SGK1 in U251 cells.
SYSUP007 potentiates TMZ efficacy by targeting the FTO/m6A/SOX9 axis.

物理化学性质&存储条件

分子量	412.40
分子式	C21H20N2O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	4,5-dihydroxy-N-(6-(hydroxyamino)-6-oxohexyl)-9,10-dioxo-9,10-dihydroanthracene-2-carboxamide

参考文献

1. Chen J, et al. Invest New Drugs. 2020 Jun;38(3):755-764.

2. Cheng L, et al. Brain Res. 2025 Aug 20;1866:149889.

SYSUP007

生物&药学活性

物理化学性质&存储条件

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SYSUP007

生物&药学活性

物理化学性质&存储条件

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