SYL1073 | MPS1/TTK inhibitor | Probechem Biochemicals

Chemical Structure : SYL1073

加入收藏

SYL1073 (SYL 1073, SYL-1073)

货号: PC-21597Not For Human Use, Lab Use Only.

SYL1073 is a potent, selective and covalent Threonine tyrosine kinase (TTK) inhibitor with IC50 of of 16 nM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SYL1073 is a potent, selective and covalent Threonine tyrosine kinase (TTK) inhibitor with IC50 of of 16 nM.
SYL1073 covalently engages with TTK at the C604 residue.
SYL1073 exhibits potent anti-proliferative activity in both MDA-MB-231 (IC50 = 0.13 μM) and HCT-116 (IC50 = 0.15 μM) cell lines.
SYL1073 exhibits excellent kinase selectivity in a panel of kinases, does not inhibit five other human kinases (CHAK1, FGFR4, MAPKAPK2, MAPKAPK3 and p70S6Kβ) that feature a cysteine residue at the equivalent position as C604 in TTK kinase.
SYL1073 effectively suppresses colony formation and induce cell cycle dysregulation and apoptosis in human breast cancer cells.

物理化学性质&存储条件

分子量	471.57
分子式	C25H29N9O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(5-(4-methyl-4H-1,2,4-triazol-3-yl)-2-((6-methyl-8-(neopentylamino)pyrido[3,4-d]pyrimidin-2-yl)amino)phenyl)acrylamide

参考文献

1. Yaoliang Sun, et al. Bioorg Chem. 2023 Dec 25:143:107053.

SYL1073 (SYL 1073, SYL-1073)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SYL1073 (SYL 1073, SYL-1073)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.