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首页-小分子抑制剂&激动剂-Antibiotics and Antivirals-Filovirus-SYC-1307
SYC-1307

Chemical Structure : SYC-1307

CAS No.: 2366220-38-2

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SYC-1307 (SYC1307)

货号: PC-23170Not For Human Use, Lab Use Only.

SYC-1307 is a potent, allosteric inhibitor of flavivirus NS2B-NS3 protease with IC50 of 0.2, 0.59, 0.59 and 0.78 uM for ZIKV, DENV2, DENV3 and WNV NS2B-NS3 respectively, shows submicromolar anti-orthoflaviviral efficacy in cells (EC50=0.3-0.6 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SYC-1307 is a potent, allosteric inhibitor of flavivirus NS2B-NS3 protease with IC50 of 0.2, 0.59, 0.59 and 0.78 uM for ZIKV, DENV2, DENV3 and WNV NS2B-NS3 respectively, shows submicromolar anti-orthoflaviviral efficacy in cells (EC50=0.3-0.6 uM).

物理化学性质&存储条件

分子量 440.55
分子式 C27H28N4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(4-(3-(4-(furan-3-yl)phenyl)-5-(piperidin-4-ylmethoxy)pyrazin-2-yl)phenyl)methanamine

参考文献

1. Nie S, et al. J. Med. Chem. 2021;64:2777–2800.

2. Lorenzo Cavina, et al. Molecules. 2024 Aug 27;29(17):4047.

3. Yao Y, et al. J. Am. Chem. Soc. 2019;141:6832–6836.

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