SY-LB-57

Chemical Structure : SY-LB-57

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货号: PC-49110Not For Human Use, Lab Use Only.

SY-LB-57 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line.

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生物&药学活性

SY-LB-57 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line.
SY-LB-57 (0.01-10 uM) stimulated canonical Smad and non-canonical PI3K/Akt, ERK, p38 and JNK intracellular signaling pathways, similar to BMP2-stimulated responses.
SY-LB-57strongly stimulate Smad phosphorylation and nuclear translocation, induce robust increases in PI3K/Akt signaling.
SY-LB-57 is a full agonists of BMP receptor signaling.

物理化学性质&存储条件

分子量	263.300
分子式	C16H13N3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(5-methoxy-1H-indol-2-yl)-1H-benzo[d]imidazole

参考文献

1. Sheyda Najafi, et al. Sci Rep. 2022 Jul 15;12(1):12146.

SY-LB-57

生物&药学活性

物理化学性质&存储条件

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SY-LB-57

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物理化学性质&存储条件

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