SX-517 |CAS:1240494-13-6 Probechem Biochemicals

Chemical Structure : SX-517

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SX-517 (Phenylboronic Acid;SX 517;SX517)

货号: PC-60620Not For Human Use, Lab Use Only.

SX-517 is a potent, specific, noncompetitive dual CXCR1 and CXCR2 antagonist with IC50 of 38 nM (vs. CXCL1) and 36 nM (vs. CXCL8), respectively.

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生物&药学活性

SX-517 is a potent, specific, noncompetitive dual CXCR1 and CXCR2 antagonist with IC50 of 38 nM (vs. CXCL1) and 36 nM (vs. CXCL8), respectively.
SX-517 inhibits CXCL1-induced Ca(2+) flux in human PMNs but has no effect on the Ca(2+) flux induced by C5a, fMLF, or PAF; antagonizes CXCL8-induced [(35)S]GTPγS binding (IC50=60 nM) and ERK1/2 phosphorylation in recombinant HEK293 cells expressed CXCR2.
SX-517significantly inhibits inflammation in an in vivo murine model (0.2 mg/kg iv).

物理化学性质&存储条件

分子量	382.216
分子式	C19H16BFN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[5-(4-Fluorophenylcarbamoyl)pyridin-2-ylsulfanylmethyl]phenylboronic Acid

参考文献

1. Maeda DY, et al. J Med Chem. 2014 Oct 23;57(20):8378-97.

2. Schuler AD, et al. Bioorg Med Chem Lett. 2015 Sep 15;25(18):3793-7.

SX-517 (Phenylboronic Acid;SX 517;SX517)

生物&药学活性

物理化学性质&存储条件

参考文献

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SX-517 (Phenylboronic Acid;SX 517;SX517)

生物&药学活性

物理化学性质&存储条件

参考文献

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