SW208108 | SCD inhibitor | Probechem Biochemicals

Chemical Structure : SW208108

加入收藏

SW208108 (SW 208108)

货号: PC-20381Not For Human Use, Lab Use Only.

SW208108 (SW 208108) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=14 nM).

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SW208108 (SW 208108) is a potent, tumor-specific, irreversible stearoyl CoA desaturase (SCD) inhibitor with high sensitity to H2122 cell (IC50=14 nM).
SW208108 cross-linked to proteins that migrated at both 37kDa (p37) and 30kDa (p30), reflective of covalent modification, p37 and p30 represent the two known isoforms of SCD.
SW208108 inhibited SCD only in the sensitive cell line, H2122, but not in the insensitive cell line, H1155.
Cytochrome P450 4F11 (CYP4F11) is responsible for oxalamide activation in sensitive cell lines and it is not expressed in insensitive cell lines.
SW208108 inhibited SCD activity in microsomes derived from liver but not from preputial glands.

物理化学性质&存储条件

分子量	456.50
分子式	C27H24N2O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N1-(4-methoxyphenethyl)-N2-(4-(4-(prop-2-yn-1-yloxy)benzoyl)phenyl)oxalamide

参考文献

1. JM, et al. Nat Chem Biol. 2016 Apr;12(4):218-25.

SW208108 (SW 208108)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SW208108 (SW 208108)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.