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首页-小分子抑制剂&激动剂-GPCR-PTH Receptor-SW106
SW106

Chemical Structure : SW106

CAS No.: 1027921-53-4

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SW106 (SW-106)

货号: PC-70262Not For Human Use, Lab Use Only.

SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SW106 is a potent, selective, competitive PTH/PTH-related peptide receptor (PPR) antagonist with IC50 of 0.99 uM.
    SW106 displays higher affinity for the PPR relative to the other GPCRs.
    SW106 specificly blocks PTH-initiated cAMP accumulation.

    物理化学性质&存储条件

    分子量 361.312
    分子式 C17H16F5NO2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (3S,5S)-5-((E)-2-cyclopropylvinyl)-3-ethyl-6,7-difluoro-5-(trifluoromethyl)-1,5-dihydrobenzo[e][1,4]oxazepin-2(3H)-one

    参考文献

    1. Carter PH, et al. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6846-51.

    2. Carter PH, et al. Mol Endocrinol. 2015 Feb;29(2):307-21.

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